Hospital officials are looking to reduce traffic on the hospital wards. The less congestion on the ward, cause that the staff work by more quality and freely also patients are waiting less. As a result it is easier to treat the patients. One of the most effective ways to reduce the patient traffic is changing the layout of the hospital. In this study, changing the layout of the hospital was explore by a case study in Shahid Behesthti Hospital. This research aims to optimize a hospital patient flow by using computerized relationship layout planning.