Academic Medical Centers (“AMCs”) have served as a hub of the United States (“US”) health system and represented the state-of-the art in American health care for well over century. Currently, the AMCs have engaged in global collaborative healthcare, employing different models based on services offered, global distribution, and inclination to assume risk. Engaging in these collaborations requires significant effort from across the health system, and an understanding of the resources required is paramount for effective delivery and to avoid overextension and diversion from the primary mission of these organizations.