In  line with the policy objetives of the United Nations sustainable Development Goals, this commentary seeks to examine the extent which provisions of international health research guidance promote capacity building and equitable partnerships in global health research. Theri evaluation finds that governance of collaborative research partnership, in resource- constrained settigns is limited but has improved with the implementation guidance of the International Ethical Guidelines for Health- related Research Involving Humans by The Council for International Organizations of Medical Sciences (CIOMS 2016)