The aim of this study was to review the evidence of the existing literature on the impact of guided self-determination across methodologies in different healthcare settings. The conclusion drawn is that overall, guided self-determination proved to have a great impact on patient important outcomes and was useful and well-accepted by the majority of patients and healthcare professionals. Albeit guided self-determination is not a ‘one size fits all’ method. Continuous training and supervision of professionals are a necessary mean when implementing guided self-determination to enhance adoption and sustainability in clinical practice.